Remarkable retinoids


Retinoids have been used in dermatology since the 1960s, and their potential in the treatment of aging was first observed in the 1980s. There are new, exciting skincare ingredients discovered all the time, so it’s easy for retinoids to get a bit forgotten in the shuffle. Taking them for granted is a huge mistake though. Almost any dermatologist or skin care specialist will tell you that second only to sunscreen; retinoids are the best anti-aging ingredient available.

What are Retinoids?

The word “retinoid” is a broad term that represents all the various derivatives of Vitamin A that are used either topically or orally (like Accutane) to fight acne, photo-aging, wrinkles, fine lines, unwanted pigmentation and more.Often people have a difficult time sticking with retinoid use, as the most effective forms tend to be irritating. But you must be consistent with retinoids to truly see what they can do. There are ways to manage irritation, which we’ll touch on in a bit. But first, let’s review the astounding things research has shown retinoids can do for your skin. To give you a small idea:

Often people have a difficult time sticking with them, as the most effective forms tend to be irritating. This could be why there aren’t a ton of people screaming from the rooftops about them. You must stick with retinoids to see what can do. We’ll get to that “tendency to be irritating” thing. What’s important to know first is that research shows they are capable of doing astounding things for your skin. To give you a small idea:

  • They increase cell turnover by increasing the rate at which new cells surface
  • They even out the complexion by interfering with excess melanin production
  • They protect collagen from degradation by getting rid of enzymes that destroy it
  • They normalize keratin production, so excess keratin doesn’t clog the pores (allowing acne bacteria to thrive)
  • They’re comedolytic (they clear clogged pores that already exist)
  • They have anti-inflammatory properties
  • They are involved in DNA repair/keeping your skin young by keeping your DNA young
  • They improve elasticity
  • They not only repair but prevent aging
  • Retinaldehyde and Differin play a role in the treatment of rosacea
  • They have been shown to improve atrophic (pitted) acne scarring
  • They are FDA approved to treat wrinkles and acne

Sign me up, right? Retinoids can be kind of tricky for most people though. They must be handled with care because of their strength and tendency to irritate. And with so many options available things can get a bit confusing.

Types of Retinoids

Retinoids are available both over the counter and with a prescription. Prescription retinoids are the strongest and include tretinoin (Retin-A) and tazarotene (Tazorac). The main retinoids found in over the counter products are retinyl palmitate, retinol, and retinaldehyde. The retinoid Adalpene (Differin) is now available over the counter at .1%, and the higher .3% strength requires a prescription.

Retinoic Acid is the only form of retinoid that directly affects your skin and is what produces all the amazing benefits. Prescription retinoids are made up of retinoic acid.

The next best thing to retinoic acid is retinaldehyde. When you apply a product that contains retinaldehyde, enzymes in your skin must convert it to retinoic acid before it can be used. Retinaldehyde is sort of like the sister of retinoic acid.

Retinol, (one of the most common active ingredients in OTC retinoid products), is more like a cousin to retinoic acid. When you apply a product that contains retinol, the enzymes in your skin must first convert it to retinaldehyde and then to retinoic acid. It requires two steps to become retinoic acid in your skin.

Finally, retinyl palmitate is like a second cousin to retinoic acid, requiring three steps to impact your skin directly.

The relationship looks like this:

          Retinyl Palmitate > Retinol > Retinaldehyde > Retinoic Acid

 It’s unclear how much retinoic acid gets lost during the conversion process.

While retinaldehyde is a more difficult active ingredient to find in over the counter beauty products (sometimes listed as retinal), it’s the most desirable for a couple of reasons. It’s not only the strongest of the three “relatives” of retinoic acid; it’s been shown to hold its own against photo-aging (when .05% was compared to .05% retinoic acid in clinical studies). It also did this without any of the irritation that comes with retinoic acid.

Osmosis Pur Medical Level 4 Vitamin A Serum: retinaldehyde, peptides, hyaluronic acid and lactic acid.

Retinaldehyde is also the best non-prescription choice for those who struggle with acne as it exhibits antibacterial activity against several strains of acne bacteria. And since it’s gentler than prescription retinoids, it’s ideal for use with other actives that can help clear acne such as a BHA.

(Note that the acne treatment benzoyl peroxide negates the effectiveness of most retinoids, so they shouldn’t be used at the same time. You could use benzoyl peroxide in the a.m., however, and retinaldehyde in the p.m. The only retinoid benzoyl peroxide doesn’t interfere with is adalpene.)

Avene TriAcneal Night
Avene knows how effective retinaldehyde is for acne prone skin. Their gentle acne products get rave reviews from sensitive skin types.
Avene Retrinal .01 shown also comes in .05 strength. Contains high levels of retinaldehyde plus peptides and antioxidant Vitamin E


Arcona Advanced A Serum has retinaldehyde fourth on its list of impressive ingredients that includes lactic acid and peptides galore.


Avene PhysioLift Night
Avene is queen when it comes to retinaldehyde, with ten products to chose from

Retinol was found to be twenty times less potent than tretinoin in clinical studies. Products containing retinol have been shown to improve lines and wrinkles; they just take longer to work than retinaldehyde or prescription retinoids do. You’ll want to look for high concentrations of retinol. If the product doesn’t specify, check the ingredients list for how far up on the list retinol appears. A relatively large amount of retinol must be delivered to skin cells to boost retinoic acid levels and produce noticeable results. If you have quite sensitive skin, however; retinol may be just what the doctor ordered.

ROC Retinol Correxion Deep Wrinkle Serum: A Women’s Day Pick, promises visible results in as little as four weeks
Neutrogena Rapid Wrinkle Repair with Retinol SA, a patented ingredient they claim has sustained action within your skin after application.


SkinMedica Retinol Complex 1.0% (also comes in .05%): Lots of niacinamide, peptides, and squalane to strengthen and soothe
Neutrogena Ageless Intensives: “sustained action retinol” plus multivitamins

You’ll find countless products containing retinol over the counter. These are just a few examples.

Products containing retinyl palmitate may be moisturizing but are likely too weak to provide a noticeable benefit regarding anti-aging. Pay attention to ingredients lists because sometimes products will claim to contain “retinol” when they actually contain retinyl palmitate.

Retinyl Retinoate

Something new in the world of retinoids is retinyl retinoate. Like retinaldehyde, this is a retinoic acid precursor (one metabolic step away from becoming retinoic acid). A team of Korean researchers had promising findings in two separate studies. They suggest that this derivative may approach retinoic acid in effectiveness without the side effect profile generally seen with such strength. It is also said to be more photo-stable than other retinoids and thus could be used twice daily. Before it can be genuinely acknowledged and established, retinyl retinoate must have its benefits proven in studies conducted by other independent researchers. Of course, that doesn’t stop cosmetic companies from creating products with it and making claims.

This retinoid derivative product won the UK Cosmopolitan Magazine award for Best New Anti-Aging Cream in 2016 $195 (actual consumer reviews are mixed)

Hydroxypinacolone Retinoate (HPR)

This is another new type of retinoid. Hydroxypinacolone retinoate is interesting because it is bioavailable to the skin in its current state, meaning no change is necessary for the skin to use it. Much like retinyl retinoate, it is said to be as effective as the “big guns” like tretinoin without the tendency to aggravate the skin as much initially.

A brand called The Ordinary makes an inexpensive HPR product ($9.60-$13.90 for one fl oz.). They call it their Granactive Retinoid line (it contains a “solubilized system of HPR” that comes from Grant Industries). I have the 5% in Squalane product, and while I haven’t been using it long enough to vouch for any actual results, I will say I’ve seen a small amount of reaction from my skin that is typical to what I get with retinoids (dryness, redness, some peeling). I probably overdid it, assuming it was gentler than it was.  The Ordinary also offers traditional retinol products starting at $5.30 for one fl oz.

The Ordinary 5% Granactive Retinoid in Squalane $13.90 for one fl oz., also available in a 2% concentration or as an emulsion (2% only)

When it comes to the prescription retinoids, Tazarotene (Tazorac, Avage, Zorac) is the strongest while Adalpene (Differin, Teva, Epiduo) is the weakest. In between the two is tretinoin (Retin-A, Renova, Retin-A micro, etc.). Some of these are marketed as “acne” retinoids and others as more for anti-aging, but I wouldn’t get too hung up on that. They all do both things quite well. (If you’re especially clog-prone, opt for a gel formula over a cream.)

When deciding which retinoid is best for you, it comes down to how your skin tolerates the product. As a rule of thumb, you want the most potent retinoid you can handle that produces the least amount of irritation. Too much irritation from a product will cancel out its benefits.  A lot of how much sensitivity you end up with has to do with how you use the product. Correct use of retinoids is the key to avoiding irritation. Click here to read about the best way to get started (or start again) with a retinoid.



J Invest Dermatol. 2005 Oct;125(4):xii-xiii.


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